The Future of Creatine

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In 1832, Michel Eugene Chevreul extracted an organic component from meat and called it creatine from the Greek word kreas, meaning flesh. It wasn’t until the early 1960s that creatine supplementation became popular among athletes to enhance strength. Synthetic creatine started to enter the market during the 1990s, while university research, demonstrating that creatine monohydrate assisted in muscle performance enhancement and strength, began to circulate in the nutritional-supplement industry.

As quickly as creatine monohydrate gained some popularity, acceptance among athletes began to slow for several reasons. They would soon discover the undesired side effects associated with creatine monohydrate. Some of those side effects included water retention, bloating and cramping as well as gastrointestinal distress. Up until now, there has been no clearly established weight-based dosage method. The most recommended dosage by supplement companies was loading at a phase of 10 to 25 grams for the first seven days, followed by a daily maintenance of 3 to 5 grams per day. When cycling off of creatine, the time frame recommended was 30 days. Regardless of body size, body type, exercise goal or gender, the dosage would be the same. How does the same dosage make sense for anybody when every body is different? When scientists asked this question, the evolution of creatine began.

A Remarkable Evolution
There are two factors that determine the bioavailability of a compound: aqueous solubility (how well the compound dissolves in water) and cellular permeability (how the compound moves across cellular, lipid-based membranes). A 2011 study involving creatine monohydrate and the now commercial form of creatine hydrochloride known as Con-Cret revealed that there is an increase in plasma creatine concentrations following ingestion but that concentrations observed in the blood following Con-Cret administration were greater compared to monohydrate. This research indicates that Con-Cret has high solubility and high permeability into intestinal cells. It shows that Con-Cret is completely or near completely absorbed (i.e., has 100 percent bioavailability).

This new form of creatine has several advantages. First, improved bioavailability means a smaller dose can be used to obtain the desired biological effects of creatine supplementation. The other is improved absorption in the intestinal tract yields superior blood plasma uptake.

Micro-Dosing Revolutionizes Creatine Dosing
Because of its improved bioavailability, Con-Cret is the first commercial HCl designed to provide a unique dosing matrix. It allows fitness enthusiasts and athletes the ability to dose based on bodyweight. The basic dose recommended is 750 milligrams for every 100 pounds of bodyweight.

Micro-dosing has several unique advantages: the ability to adjust dosing for specific workout goals when intense muscle activity is present, the absence of loading, no cycle-off period and gender-based dosing specific to body type and composition. Post-dosing is recommended to maintain creatine stores in muscle tissue to assist in recovery.

Getting Energized
Muscle cells require continual energy, and adenosine triphosphate is that immediate energy source. Creatine is essential to ATP generation; therefore, absorption of creatine is critical to creating energy in muscle cells. Increased solubility of creatine and the body will see enhanced absorption to the cell.

ATP is being constantly used and regenerated in cells via a process known as cellular respiration. Therefore, the presence of creatine is vital to maintaining ATP regeneration. Any diminished creatine levels will result in a decrease of ATP production, resulting in muscle fatigue.

Mike Bridges, age 55, and Dave Ricks, age 53, are examples of the profound benefits of Con-Cret micro-dosing. Both men compete in powerlifting in the 198-pound class and are lifting more than they did decades ago. In 2009, at the Pan-American Games, Bridges recorded an 804-pound squat and a 511-pound bench. His bench was his personal best, and his squat just missed the world record of 837 pounds he set 25 years ago. In 2012, Ricks had his personal best and a masters world record with a squat of 777 pounds, a personal-best bench of 501 pounds and a deadlift of 744 pounds.

Bridges and Ricks believe that Con-Cret is the reason for their increased strength and performance. They report that the surge in muscle energy is something they have never experienced from other creatines. For all these reasons, Con-Cret is one of the best creatine products on the market.